The answer was . The correct answer was anti-Hu associated paraneoplastic encephalomyelitis/sensory neuronopathy .
Here’s a short, useful story that illustrates how approaching a Kaplan Step 1 Question of the Day —even getting it wrong—can teach you more than memorizing a fact. The Question That Made Dr. Mehta a Better Teacher
The neurologist had ordered anti-Hu antibodies, which came back positive. A follow-up PET-CT showed a tiny 1.2 cm hilar focus – small cell lung cancer. kaplan step 1 question of the day
She sighed. Another esoteric fact I’ll never see again.
One Tuesday, the question read: A 45-year-old man with a 30-pack-year smoking history presents with hemoptysis and weight loss. A chest CT shows a 4 cm central right hilar mass. Bronchoscopy with biopsy reveals small cells with scant cytoplasm, nuclear molding, and high mitotic rate. Which paraneoplastic syndrome is most likely to occur early and be detectable serologically before the cancer is visible on imaging? Samira thought: Small cell lung cancer → paraneoplastic → SIADH or Lambert-Eaton? She quickly chose (antibodies against presynaptic voltage-gated calcium channels). The answer was
The resident raised an eyebrow. “Where’d you learn that?”
“A question I got wrong,” Samira said. “Best teacher I’ve had.” A single Kaplan Step 1 Question of the Day is not just a test of knowledge – it’s a clinical pearl delivery system. When you get one wrong, don’t just memorize the fact. Learn the pattern that would make you recognize it in a real patient before anyone else does. That’s what Step 1 – and being a great doctor – is really about. The Question That Made Dr
Samira remembered the Kaplan Question of the Day. She explained the case to her resident, adding: “The antibody can appear before the tumor is visible on CT. That’s why we check it early.”