| Tool | Description | |------|-------------| | | Latest stable version – similar interface, fewer bugs. | | PyRx 0.8 | GUI for AutoDock Vina – easier for beginners. | | AutoDock Vina + Open Babel | Command-line workflow, no GUI needed. | | QDock | Modern Qt-based GUI for AutoDock. | | Docker + ADT | Run legacy ADT in a container on modern OS. | Final Checklist ✅ Downloaded from Scripps FTP or official registration site ✅ Correct installer for your OS and architecture ✅ MD5 checksum matched (optional) ✅ Installed in a short path without spaces ✅ Launched successfully and loaded a PDB file
If you encounter persistent issues, consider upgrading to ADT 1.5.7 or switching to PyRx, as ADT 1.5.6 is no longer supported and uses deprecated Python 2.7. Autodock Tools 1.5 6 Download
sudo apt install libx11-6 libxext6 libxt6 libsm6 libice6 libgl1-mesa-glx | Problem | Solution | |---------|----------| | "Python 2.7 not found" | ADT 1.5.6 includes its own Python – don't use system Python. | | White screen / GUI not rendering | Disable 3D acceleration in VM or set export TK_AGL=0 (macOS). | | macOS “damaged” error | Remove quarantine: xattr -d com.apple.quarantine /Applications/MGLTools-1.5.6.app | | Cannot write to install dir | Install in user-owned folder (Linux/macOS) or run as Admin (Windows). | Modern Alternatives to ADT 1.5.6 If you don't specifically need version 1.5.6, consider: | Tool | Description | |------|-------------| | |
wget ftp://ftp.scripps.edu/pub/olson-web/mgltools/1.5.6/mgltools_1.5.6_Linux_x86_64_installer.tar.gz Check the MD5 checksum (provided on the FTP site in MD5SUM.txt ). Example for Linux 64-bit: | | QDock | Modern Qt-based GUI for AutoDock